Issue 65, 2021
From the journal:

Chemical Communications

Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation†

Masaki Hagihara ORCID logo a  

a Graduate School of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan
E-mail: hagihara@hirosaki-u.ac.jp

Abstract

We demonstrate that an RNA template containing eight GGG repeat sequences exhibits a unique tandem G-quadruplex structure in which two individual G-quadruplexes are aligned in close proximity. Because of their unexpected stability, tandem G-quadruplexes formed in the coding region of mRNA strands effectively inhibited in vitro protein synthesis.

Graphical abstract: Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation

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Article information

DOI
https://doi.org/10.1039/D1CC02995A
Article type
Communication
Submitted
07 Jun 2021
Accepted
18 Jul 2021
First published
20 Jul 2021

Chem. Commun., 2021,57, 8063-8066

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Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation

M. Hagihara, Chem. Commun., 2021, 57, 8063 DOI: 10.1039/D1CC02995A

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