Issue 69, 2021

Copper-catalyzed aerobic double functionalization of benzylic C(sp3)–H bonds for the synthesis of 3-hydroxyisoindolinones

Abstract

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)–H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)–H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)–H bonds and shows excellent functional group tolerance.

Graphical abstract: Copper-catalyzed aerobic double functionalization of benzylic C(sp3)–H bonds for the synthesis of 3-hydroxyisoindolinones

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2021
Accepted
29 Jul 2021
First published
30 Jul 2021

Chem. Commun., 2021,57, 8604-8607

Copper-catalyzed aerobic double functionalization of benzylic C(sp3)–H bonds for the synthesis of 3-hydroxyisoindolinones

K. Nozawa-Kumada, Y. Matsuzawa, K. Ono, M. Shigeno and Y. Kondo, Chem. Commun., 2021, 57, 8604 DOI: 10.1039/D1CC02870G

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