Issue 53, 2021
From the journal:

Chemical Communications

Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants†

Yuanyuan Zhang,‡a   Xiaoyan Zhang,‡a   Huan Cheng,‡a   Mario Roque Huanca Nina,a   Jun Ge ORCID logo *b  and  Yunpeng Bai ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: ybai@ecust.edu.cn

b Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
E-mail: junge@mail.tsinghua.edu.cn

Abstract

Engineering of a promiscuous lactonase via semi-rational evolution gave a 1007-fold improvement in its catalytic activity in the degradation of triphenyl phosphate (TPHP). TPHP is a typical bulky organophosphate flame retardant (OPFR) and is widely used in industry. To the best of our knowledge, this is the first artificial enzyme capable of degrading OPFRs.

Graphical abstract: Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

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Article information

DOI
https://doi.org/10.1039/D1CC02657G
Article type
Communication
Submitted
20 May 2021
Accepted
03 Jun 2021
First published
04 Jun 2021

Chem. Commun., 2021,57, 6475-6478

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Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

Y. Zhang, X. Zhang, H. Cheng, M. R. H. Nina, J. Ge and Y. Bai, Chem. Commun., 2021, 57, 6475 DOI: 10.1039/D1CC02657G

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