Issue 66, 2021
From the journal:

Chemical Communications

Deoxyfluorination of alcohols with aryl fluorosulfonates†

Xiu Wang, ORCID logo ‡a   Min Zhou,‡a   Qinghe Liu,‡a   Chuanfa Ni,a   Zhongbo Fei,§b   Wei Li ORCID logo b  and  Jinbo Hu ORCID logo *a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China
E-mail: jinbohu@sioc.ac.cn

b Chemical and Analytical Development, Suzhou Novartis Pharma Technology Co., Ltd, Changshu, Jiangsu 215537, P. R. China

Abstract

Aryl fluorosulfonates are developed as a deoxyfluorinating reagent in the transformation of primary and secondary alcohols into the corresponding alkyl fluorides. These reagents feature easy availability, low-cost, high stability and high efficiency. Diverse functionalities including aldehyde, ketone, ester, halogen, nitro, alkene, and alkyne are well tolerated under mild reaction conditions.

Graphical abstract: Deoxyfluorination of alcohols with aryl fluorosulfonates

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Article information

DOI
https://doi.org/10.1039/D1CC02617H
Article type
Communication
Submitted
18 May 2021
Accepted
02 Jul 2021
First published
03 Jul 2021

Chem. Commun., 2021,57, 8170-8173

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Deoxyfluorination of alcohols with aryl fluorosulfonates

X. Wang, M. Zhou, Q. Liu, C. Ni, Z. Fei, W. Li and J. Hu, Chem. Commun., 2021, 57, 8170 DOI: 10.1039/D1CC02617H

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