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Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

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Abstract

Asymmetric allylic CH alkylation of 1,4-pentadienes with α-angelica lactones has been developed by tri-axial phosphoramidite-palladium catalysis. This reaction can tolerate a range of functional groups under mild conditions, furnishing versatile chiral γ,γ-disubstituted butenolides in high yields with good to high levels of stereoselectivity.

Graphical abstract: Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

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Article information


Submitted
29 Apr 2021
Accepted
10 Jun 2021
First published
11 Jun 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes

Z. Dai, P. Wang and L. Gong, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC02295D

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