Issue 49, 2021

A computationally designed β-amino acid-containing miniprotein

Abstract

A new miniprotein built from three helices, including one structure based on the ααβαααβ sequence pattern was developed. Its crystal structure revealed a compact conformation with a well-packed hydrophobic core of unprecedented structure. The miniprotein formed dimers that were stabilized by the interaction of their hydrophobic surfaces.

Graphical abstract: A computationally designed β-amino acid-containing miniprotein

Supplementary files

Article information

Article type
Communication
Submitted
25 Apr 2021
Accepted
12 May 2021
First published
12 May 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 6015-6018

A computationally designed β-amino acid-containing miniprotein

M. Bejger, P. Fortuna, M. Drewniak-Świtalska, J. Plewka, W. Rypniewski and Ł. Berlicki, Chem. Commun., 2021, 57, 6015 DOI: 10.1039/D1CC02192C

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