Recent advances in directed sp2 C–H functionalization towards the synthesis of N-heterocycles and O-heterocycles

Abstract

Heterocyclic compounds are widely present in the core structures of several natural products, pharmaceuticals and agrochemicals, and thus great efforts have been devoted to their synthesis in a mild and simpler way. In the past decade, remarkable progress has been made in the field of heterocycle synthesis by employing C–H functionalization as an emerging synthetic strategy. As a complement to previous protocols, transition metal catalyzed C–H functionalization of arenes using various directing groups has recently emerged as a powerful tool to create different classes of heterocycles. This review is mainly focussed on the recent key progress made in the field of the synthesis of N,O-heterocycles from olefins and allenes by using nitrogen based and oxidizing directing groups.