Issue 49, 2021

Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones

Abstract

The Pd(II)-catalyzed activation of Csp2–H bond and double alkyne annulation which proceeds via allylic isomerization is reported for the first time. This reaction of antipyrines with alkynes provides an efficient synthetic route for the biologically important spiro-cyclopentadiene pyrazolones. In the presence of Lawesson's reagent, this Pd(II)-catalyzed annulation reaction affords another spiro-cyclopentadiene pyrazolone which displays very good fluorescence properties.

Graphical abstract: Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones

Supplementary files

Article information

Article type
Communication
Submitted
23 Apr 2021
Accepted
11 May 2021
First published
12 May 2021

Chem. Commun., 2021,57, 6027-6030

Pd(II)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones

S. Changmai, S. Sultana, B. Sarma and S. Gogoi, Chem. Commun., 2021, 57, 6027 DOI: 10.1039/D1CC02155A

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