A catalytic triplex DNAzyme for porphyrin metalation

Xiong Zheng; Mujing Yang; Tong Yang; Yun Chang; Shuzhen Peng; Qiuda Xu; Dandan Wang; Xiaoshun Zhou; Yong Shao

doi:10.1039/D1CC01955D

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A catalytic triplex DNAzyme for porphyrin metalation†

Xiong Zheng,^a Mujing Yang,^a Tong Yang,^a Yun Chang,^a Shuzhen Peng,^a Qiuda Xu,^a Dandan Wang,^a Xiaoshun Zhou^a and Yong Shao

*^a

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* Corresponding authors

^a Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Institute of Physical Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, Zhejiang, China
E-mail: yshao@zjnu.cn

Abstract

Trihydroxyphenyl porphyrin (POH₃) was designed to specifically bind with a triplex DNA resulting in a turn-on fluorescence response. This ensemble can be developed into a catalytic triplex DNAzyme towards porphyrin metalation. The catalytic activity is initiated by the enhanced basicity of POH₃ upon binding with the triplex DNA.

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Article information

DOI: https://doi.org/10.1039/D1CC01955D
Article type: Communication
Submitted: 13 Apr 2021
Accepted: 27 May 2021
First published: 27 May 2021

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Chem. Commun., 2021,57, 6499-6502

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A catalytic triplex DNAzyme for porphyrin metalation

X. Zheng, M. Yang, T. Yang, Y. Chang, S. Peng, Q. Xu, D. Wang, X. Zhou and Y. Shao, Chem. Commun., 2021, 57, 6499 DOI: 10.1039/D1CC01955D

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Chemical Communications

A catalytic triplex DNAzyme for porphyrin metalation†

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A catalytic triplex DNAzyme for porphyrin metalation

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