A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.
J. Liu, S. Zhong, L. Zhang, M. Yi, X. Liu, T. Bing, N. Zhang and D. Shangguan, Chem. Commun., 2021, 57, 6558 DOI: 10.1039/D1CC01847G
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