Issue 52, 2021
From the journal:

Chemical Communications

Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits†

Yaxi Li,‡a   Zeshun Li,‡a   Dehong Hu,‡b   Shuxian Wang,a   Menglei Zha,a   Song-Bo Lu, ORCID logo a   Zonghai Sheng ORCID logo b  and  Kai Li ORCID logo *a  

* Corresponding authors

a Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
E-mail: lik@sustech.edu.cn

b Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Institute of Bio-medical and Health Engineering, Shenzhen Institutes of Advance Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Abstract

The functional NIR-II emissive nanoprobe loaded with AIEgen (cRGD-TTB NPs) achieved a high quantum yield (10.32%) and a high signal-to-background (S/B) ratio of 7.7 when employed for the visualization of large tumors (∼600 mm3) in rabbit models for the first time. This work will aid in the investigation of tumor targeting effect of therapeutic agents in large animal models.

Graphical abstract: Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits

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Article information

DOI
https://doi.org/10.1039/D1CC01804C
Article type
Communication
Submitted
05 Apr 2021
Accepted
26 May 2021
First published
26 May 2021

Chem. Commun., 2021,57, 6420-6423

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Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits

Y. Li, Z. Li, D. Hu, S. Wang, M. Zha, S. Lu, Z. Sheng and K. Li, Chem. Commun., 2021, 57, 6420 DOI: 10.1039/D1CC01804C

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