Jump to main content
Jump to site search


Amide bond formation: beyond the dilemma between activation and racemisation

Author affiliations

Abstract

The development of methods for amide bond formation without recourse to typical condensation reagents has become an emerging research area and has been actively explored in the past quarter century. Inspired by the structure of vitamin B12, we have developed a metal-templated macrolactamisation that generates a new wave towards classical macrolactam synthesis. Further, distinct from the extensively used methods with condensation reagents or catalysts based on catalyst/reagent control our metal-catalysed methods based on substrate control can effectively address long-standing challenges such as racemisation in the field of peptide chemistry. In addition, the substrate-controlled strategy demonstrates the feasibility of “remote” peptide bond-forming reaction catalysed by a metal–ligand complex. Moreover, an originally designed hydrosilane/aminosilane system can avoid not only racemisation but also unnecessary waste production. This feature article documents our discovery and application of our original approaches in amide bond formation.

Graphical abstract: Amide bond formation: beyond the dilemma between activation and racemisation

Back to tab navigation

Article information


Submitted
05 Apr 2021
Accepted
07 Jun 2021
First published
10 Jun 2021

Chem. Commun., 2021, Advance Article
Article type
Feature Article

Amide bond formation: beyond the dilemma between activation and racemisation

W. Muramatsu, T. Hattori and H. Yamamoto, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC01795K

Social activity

Search articles by author

Spotlight

Advertisements