Jump to main content
Jump to site search


Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

Author affiliations

Abstract

SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.

Graphical abstract: Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

Back to tab navigation

Supplementary files

Article information


Submitted
01 Apr 2021
Accepted
14 May 2021
First published
14 May 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

M. V. F. Ferraz, E. G. Moreira, D. F. Coêlho, G. L. Wallau and R. D. Lins, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC01747K

Social activity

Search articles by author

Spotlight

Advertisements