Selective primary aniline synthesis through supported Pd-catalyzed acceptorless dehydrogenative aromatization by utilizing hydrazine

Abstract

By utilizing hydrazine (N₂H₄) as the nitrogen source in the presence of a hydroxyapatite-supported Pd nanoparticle catalyst (Pd/HAP), various primary anilines can be selectively synthesized from cyclohexanones via acceptorless dehydrogenative aromatization. The strong nucleophilicity of N₂H₄ and the stability of the hydrazone intermediates can effectively suppress the formation of the undesired secondary aniline byproducts.