Enantioselective decarboxylative protonation of tetralone-derived β-ketocarboxylic acids was achieved with up to 89% enantiomeric excess (ee)–in the presence of a chiral primary amine catalyst. Furthermore, this method was applied to enantioselective deuteration to afford the corresponding α-deuterioketones with up to 88% ee.
H. Mizutani, R. Kawanishi and K. Shibatomi, Chem. Commun., 2021, 57, 6676 DOI: 10.1039/D1CC01610E
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