Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide

Thanawat Suwatthanarak; Masayoshi Tanaka; Yoshitaka Miyamoto; Kenji Miyado; Mina Okochi

doi:10.1039/D1CC01295A

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Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide†

Thanawat Suwatthanarak,

^a Masayoshi Tanaka,

^a Yoshitaka Miyamoto,^b Kenji Miyado^b and Mina Okochi

*^a

Author affiliations

* Corresponding authors

^a Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8552, Japan
E-mail: okochi.m.aa@m.titech.ac.jp

^b Department of Reproductive Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan

Abstract

A CD9-binding peptide (RSHRLRLH), screened from EWI-2, was characterized, and its effect on cellular migration and invasion was evaluated. As CD9 protein is overexpressed in cancer cells and plays an important role in cellular migration, the CD9-binding peptide preferentially inhibited the migration of cancer cells. Unlike conventional antiproliferative drugs, this CD9-binding peptide is promising as a novel precision antimigratory agent for cancer therapeutics.

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Article information

DOI: https://doi.org/10.1039/D1CC01295A
Article type: Communication
Submitted: 10 Mar 2021
Accepted: 09 Apr 2021
First published: 19 Apr 2021

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Chem. Commun., 2021,57, 4906-4909

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Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide

T. Suwatthanarak, M. Tanaka, Y. Miyamoto, K. Miyado and M. Okochi, Chem. Commun., 2021, 57, 4906 DOI: 10.1039/D1CC01295A

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Chemical Communications

Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide†

Abstract

Supplementary files

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Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide

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