Issue 35, 2021

Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides

Abstract

The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides from isocyanides, 2-iodoanilines and carboxylic acids has been developed. This method provides expeditious and highly efficient access to structurally diverse N-acyl anthranilamides from readily available starting materials with good functional group compatibility. The utility of this method has been demonstrated by the late stage functionalization of two commercial drugs: Flurbiprofen and Loxoprofen.

Graphical abstract: Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2021
Accepted
19 Mar 2021
First published
23 Mar 2021

Chem. Commun., 2021,57, 4247-4250

Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides

T. Yao, B. Wang, B. Ren, X. Qin and T. Li, Chem. Commun., 2021, 57, 4247 DOI: 10.1039/D1CC01226F

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