Two-photon fluorescence and MR bio-imaging of endogenous H2O2 in the tumor microenvironment using a dual-mode nanoprobe

Hongmei Zhong; Shengrong Yu; Bingqian Li; Kangdi He; Dian Li; Xiao Wang; Yong-Xiang Wu

doi:10.1039/D1CC01129D

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Two-photon fluorescence and MR bio-imaging of endogenous H₂O₂ in the tumor microenvironment using a dual-mode nanoprobe†

Hongmei Zhong,^a Shengrong Yu,*^ab Bingqian Li,^a Kangdi He,^a Dian Li,^a Xiao Wang*^c and Yong-Xiang Wu

*^ab

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* Corresponding authors

^a State Key Laboratory Base of Novel Functional Materials and Preparation Science, Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang, China
E-mail: yushengrong@nbu.edu.cn, wuyongxiang@nbu.edu.cn

^b Institute of Mass Spectrometry, Ningbo University, Ningbo, China

^c Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, Zhejiang, China
E-mail: wangxiao@nbu.edu.cn

Abstract

The dual-mode bio-imaging nanoprobe TP-CQDs@MnO₂, based on two-photon carbon quantum dots and MnO₂, has been developed for the two-photon fluorescence and MR imaging of endogenous H₂O₂ in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detection (LOD) of 1.425 pM for H₂O₂, and a two-photon tissue penetration depth of 280 μm.

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Article information

DOI: https://doi.org/10.1039/D1CC01129D
Article type: Communication
Submitted: 01 Mar 2021
Accepted: 19 May 2021
First published: 19 May 2021

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Chem. Commun., 2021,57, 6288-6291

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Two-photon fluorescence and MR bio-imaging of endogenous H₂O₂ in the tumor microenvironment using a dual-mode nanoprobe

H. Zhong, S. Yu, B. Li, K. He, D. Li, X. Wang and Y. Wu, Chem. Commun., 2021, 57, 6288 DOI: 10.1039/D1CC01129D

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Chemical Communications