A single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1

Juan Hu; Jie Yao; Jufeng Wang; Li-yuan Pan; Jian-Ge Qiu; Chun-yang Zhang

doi:10.1039/D1CC01057C

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A single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1†

Juan Hu,‡^ab Jie Yao,‡^a Jufeng Wang,‡^c Li-yuan Pan,^a Jian-Ge Qiu*^d and Chun-yang Zhang

*^a

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* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China
E-mail: cyzhang@sdnu.edu.cn
Fax: +86 531-82615258
Tel: +86 531-86186033

^b School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China

^c Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China

^d Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
E-mail: jiangeqiu@zzu.edu.cn

Abstract

We developed a single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1 (TET1). This biosensor can sensitively detect TET1 in a homogeneous manner without the involvement of any specific antibodies, and it can be used for accurate measurement of TET1 activity in human neuroblastoma cells and the screening of TET1 inhibitors.

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Article information

DOI: https://doi.org/10.1039/D1CC01057C
Article type: Communication
Submitted: 24 Feb 2021
Accepted: 19 Mar 2021
First published: 19 Mar 2021

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Chem. Commun., 2021,57, 3543-3546

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A single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1

J. Hu, J. Yao, J. Wang, L. Pan, J. Qiu and C. Zhang, Chem. Commun., 2021, 57, 3543 DOI: 10.1039/D1CC01057C

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Chemical Communications

A single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1†

Abstract

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A single quantum dot-based fluorescence resonance energy transfer biosensor for antibody-free detection of ten-eleven translocation 1

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