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Targeted pH Switched Europium Complexes Monitoring Receptor Internalisation in Living Cells

Abstract

We report the design and evaluation of pH responsive luminescent europium(III) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to monitor uptake into more acidic organelles, thereby enhancing the performance of time-resolved internalisation assays that require pH monitoring in real time.

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Article information


Submitted
23 Feb 2021
Accepted
04 May 2021
First published
04 May 2021

This article is Open Access

Chem. Commun., 2021, Accepted Manuscript
Article type
Communication

Targeted pH Switched Europium Complexes Monitoring Receptor Internalisation in Living Cells

D. Parker, J. Fradgley, M. starck, J. M. Zwier, L. Lamarque, E. Trinquet, M. Laget, E. Bourrier and E. Dupuis, Chem. Commun., 2021, Accepted Manuscript , DOI: 10.1039/D1CC01029H

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