Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

Xiangnan Wang; Lan Liu; Han Wu; Zhenkun Wu; Li-Juan Tang; Jian-Hui Jiang

doi:10.1039/D1CC00481F

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Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing†

Xiangnan Wang,^a Lan Liu,^a Han Wu,^a Zhenkun Wu,

*^a Li-Juan Tang^a and Jian-Hui Jiang

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: tomwu@hnu.edu.cn, jianhuijiang@hnu.edu.cn

Abstract

A dual-aptamer based AND logic cascade circuit is activated on cell membranes in response to the receptor–aptamer binding, affording enhanced specificity for cell subtype recognition and gene silencing.

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Article information

DOI: https://doi.org/10.1039/D1CC00481F
Article type: Communication
Submitted: 27 Jan 2021
Accepted: 09 Mar 2021
First published: 10 Mar 2021

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Chem. Commun., 2021,57, 3816-3819

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Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

X. Wang, L. Liu, H. Wu, Z. Wu, L. Tang and J. Jiang, Chem. Commun., 2021, 57, 3816 DOI: 10.1039/D1CC00481F

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Chemical Communications

Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing†

Abstract

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Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

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