Pd-Catalyzed sp3 C–H alkoxycarbonylation of 8-methylquinolines using Mo(CO)6 as a CO surrogate

Abstract

A Pd(II)-catalyzed three-component sp³ C–H alkoxycarbonylation of 8-methylquinonlines (8-MQs) with alcohols is accomplished using the colorless crystalline Mo(CO)₆ as a CO source. The protocol is compatible with a wide range of 8-MQs and alcohols, furnishing the carbonylated adducts in moderate to good yields. The substrate scope, functional group tolerance and natural product mutation are the important practical features.