Issue 25, 2021

Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer

Abstract

Fluorinated 5-hydroxytryptophans (Fn-5HOWs) were synthesized in gram scale quantities and incorporated into a β-hairpin peptide and the protein azurin. The redox-active Fn-5HOWs exhibit unique radical spectroscopic signatures that expand the function of 5HOW as probes for biological electron transfer.

Graphical abstract: Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2021
Accepted
10 Feb 2021
First published
11 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 3107-3110

Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer

A. Ohler, H. Long, K. Ohgo, K. Tyson, D. Murray, A. Davis, C. Whittington, E. G. Hvastkovs, L. Duffy, A. Haddy, A. L. Sargent, W. E. Allen and A. R. Offenbacher, Chem. Commun., 2021, 57, 3107 DOI: 10.1039/D1CC00187F

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