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Single-molecule determination of chemical equilibrium of DNA intercalation by electrical conductance

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Abstract

We investigated a single-molecule reaction of DNA intercalation as an example of a bimolecular association reaction. Single-molecule conductance values of the product and reactant molecules adsorbed on an Au surface were measured to identify and quantify these molecules. The binding isotherm was constructed, and the association constant of the reaction was determined on a single-molecule basis.

Graphical abstract: Single-molecule determination of chemical equilibrium of DNA intercalation by electrical conductance

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Article information


Submitted
25 Dec 2020
Accepted
07 Apr 2021
First published
08 Apr 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Single-molecule determination of chemical equilibrium of DNA intercalation by electrical conductance

L. Zhang, S. Kaneko, S. Fujii, M. Kiguchi and T. Nishino, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D0CC08348H

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