Mn–DNA coordination of nanoparticles for efficient chemodynamic therapy

Abstract

A kind of nanoparticle is developed for highly efficient chemodynamic therapy that only relies on the endogenous H₂O₂ of cancer cells. For this nanoparticle, high-molecular-weight DNA is used as the biocompatible carrier to load abundant Mn²⁺ ions. Therefore, the resultant Mn–DNA coordination nanoparticles can efficiently deliver and sensitively release Mn²⁺ in cancer cells, resulting in high toxicity through the Fenton-like reaction.