Issue 14, 2021
From the journal:

Chemical Communications

Substituted meso-vinyl-BODIPY as thiol-selective fluorogenic probes for sensing unfolded proteins in the endoplasmic reticulum†

Huiying Mu,a   Koji Miki,*a   Takuya Kubo, ORCID logo b   Koji Otsuka ORCID logo b  and  Kouichi Ohe ORCID logo *a  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: kojimiki@scl.kyoto-u.ac.jp, ohe@scl.kyoto-u.ac.jp

b Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

Abstract

A new type of thiol probes based on the meso-vinyl-BODIPY (VB) scaffold were developed. The monochloro-substituted VB1Cl exhibited the largest fluorescence enhancement (>200-fold) as well as high selectivity upon biological thiol sensing. VB1Cl was successfully applied for reporting the protein unfolding process under ER stress in living cells.

Graphical abstract: Substituted meso-vinyl-BODIPY as thiol-selective fluorogenic probes for sensing unfolded proteins in the endoplasmic reticulum

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC08160D
Article type
Communication
Submitted
16 Dec 2020
Accepted
06 Jan 2021
First published
15 Jan 2021

Chem. Commun., 2021,57, 1818-1821

Permissions

Request permissions

Substituted meso-vinyl-BODIPY as thiol-selective fluorogenic probes for sensing unfolded proteins in the endoplasmic reticulum

H. Mu, K. Miki, T. Kubo, K. Otsuka and K. Ohe, Chem. Commun., 2021, 57, 1818 DOI: 10.1039/D0CC08160D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements