Issue 21, 2021
From the journal:

Chemical Communications

Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA†

Xin Liu, ORCID logo a   Fanyu Meng,b   Rui Sun,c   Kangnan Wang, ORCID logo a   Zhiqiang Yu ORCID logo *ac  and  Peng Miao ORCID logo *bd  

* Corresponding authors

a Department of Pharmacy, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan 528300, China
E-mail: yuzq@smu.edu.cn

b Ji Hua Laboratory, Foshan 528200, China
E-mail: miaopeng@sibet.ac.cn

c Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

d Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China

Abstract

In this work, we have developed a simple and reliable platform for simultaneous analysis of telomerase and miRNA. A three-dimensional bipedal DNA walking strategy is designed utilizing gold nanoparticles and MnO2 nanosheets. Given the merits of fast, sensitive and selective analysis, the developed method has great potential application in early clinical diagnosis.

Graphical abstract: Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA

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Article information

DOI
https://doi.org/10.1039/D0CC08089F
Article type
Communication
Submitted
13 Dec 2020
Accepted
31 Jan 2021
First published
02 Feb 2021

Chem. Commun., 2021,57, 2629-2632

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Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA

X. Liu, F. Meng, R. Sun, K. Wang, Z. Yu and P. Miao, Chem. Commun., 2021, 57, 2629 DOI: 10.1039/D0CC08089F

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