Issue 18, 2021

A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

Abstract

The archetypal tris(benzyltriazolemethyl)amine (TBTA) ligand was equipped with a bowl-shaped cap in the cage Hm-TBTA. Hm-TBTA accelerates CuAAC reactions without suffering from product inhibition. Furthermore, this shielded ligand efficiently protects the copper center from deactivation by the CuI–chelator glutathione, opening the way to novel approaches for efficient CuAAC reactions in complex media.

Graphical abstract: A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2020
Accepted
25 Jan 2021
First published
26 Jan 2021

Chem. Commun., 2021,57, 2281-2284

A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

G. Qiu, P. Nava, A. Martinez and C. Colomban, Chem. Commun., 2021, 57, 2281 DOI: 10.1039/D0CC08005E

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