Issue 15, 2021
From the journal:

Chemical Communications

Hydrogen sulfide triggered molecular agent for imaging and cancer therapy†

Chao Ge, ORCID logo a   Xiaojiao Di,a   Siqi Han,bc   Mengmeng Wang,a   Xiaoting Qian,a   Zhi Su,a   Hong-Ke Liu ORCID logo *a  and  Yong Qian ORCID logo *a  

* Corresponding authors

a School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing, P. R. China
E-mail: liuhongke@njnu.edu.cn, yongqian@njnu.edu.cn

b Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, P. R. China

c Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, P. R. China

Abstract

We developed an activatable molecular reagent, PNF, triggered by intracellular H2S in the lysosome to release the therapeutic drug amonafide, which can escape from the lysosome into the nucleus to induce autophagy of cancer cells. PNF exhibits potent inhibitory activity against cisplatin-resistant tumor cell lines.

Graphical abstract: Hydrogen sulfide triggered molecular agent for imaging and cancer therapy

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Article information

DOI
https://doi.org/10.1039/D0CC07982K
Article type
Communication
Submitted
08 Dec 2020
Accepted
20 Jan 2021
First published
21 Jan 2021

Chem. Commun., 2021,57, 1931-1934

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Hydrogen sulfide triggered molecular agent for imaging and cancer therapy

C. Ge, X. Di, S. Han, M. Wang, X. Qian, Z. Su, H. Liu and Y. Qian, Chem. Commun., 2021, 57, 1931 DOI: 10.1039/D0CC07982K

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