Issue 6, 2021
From the journal:

Chemical Communications

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells†

Li-Song Zhang,a   Hong-Lei Xu,a   Ying Xia,a   Jian-Peng Bi,a   Chuan-Zeng Zhang,a   Zhen Xi,b   Lu-Yuan Lia  and  Zhi-Song Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, NanKai University, Tianjin 300350, China
E-mail: zzs@nankai.edu.cn

b Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China

Abstract

Caspase-3/8 are key members of the cysteine–aspartyl protease family with pivotal roles in apoptosis. We have designed and synthesized self-assembling probes, Nap-GFFpYDEVD-AFC and Nap-GFFpYIETD-AFC, with fluorescence ‘turn-on’ properties for real-time monitoring of Caspase-3/8 activity in living cells.

Graphical abstract: Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

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Article information

DOI
https://doi.org/10.1039/D0CC07821B
Article type
Communication
Submitted
01 Dec 2020
Accepted
15 Dec 2020
First published
15 Dec 2020

Chem. Commun., 2021,57, 797-800

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Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

L. Zhang, H. Xu, Y. Xia, J. Bi, C. Zhang, Z. Xi, L. Li and Z. Zhang, Chem. Commun., 2021, 57, 797 DOI: 10.1039/D0CC07821B

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