Issue 21, 2021
From the journal:

Chemical Communications

Aβ aggregation behavior at interfaces with switchable wettability: a bioinspired perspective to understand amyloid formation†

Yijia Guan, ORCID logo ab   Dongqin Yu,ac   Hanjun Sun,a   Jinsong Ren ORCID logo ac  and  Xiaogang Qu ORCID logo *ac  

* Corresponding authors

a Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
E-mail: xqu@ciac.ac.cn

b Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Henan, Jiaozuo, P. R. China

c University of Science and Technology of China, Hefei, Anhui, P. R. China

Abstract

An amphiphilic taurocholic acid (TCA) doped polypyrrole (PPy) film (PPy/TCA) was used as a dynamic mimic membrane model to explore how switchable surface wettability influences amyloid aggregation. Our results indicate that the hydrophobic surface, not the hydrophilic surface, plays important roles in Aβ40 adsorption and aggregation.

Graphical abstract: Aβ aggregation behavior at interfaces with switchable wettability: a bioinspired perspective to understand amyloid formation

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Article information

DOI
https://doi.org/10.1039/D0CC07546A
Article type
Communication
Submitted
17 Nov 2020
Accepted
31 Jan 2021
First published
01 Feb 2021

Chem. Commun., 2021,57, 2641-2644

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Aβ aggregation behavior at interfaces with switchable wettability: a bioinspired perspective to understand amyloid formation

Y. Guan, D. Yu, H. Sun, J. Ren and X. Qu, Chem. Commun., 2021, 57, 2641 DOI: 10.1039/D0CC07546A

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