Issue 5, 2021

Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach

Abstract

Regioselective and stereospecific directed C–H arylation of simple amine substrates, and cyclisation, delivered 30 diverse, three-dimensional scaffolds. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring.

Graphical abstract: Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach

Supplementary files

Article information

Article type
Communication
Submitted
20 Oct 2020
Accepted
09 Dec 2020
First published
21 Dec 2020

Chem. Commun., 2021,57, 599-602

Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach

S. Rice, D. J. Cox, S. P. Marsden and A. Nelson, Chem. Commun., 2021, 57, 599 DOI: 10.1039/D0CC06975B

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