Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.
B. Mondal, T. Dutta and S. Sen Gupta, Chem. Commun., 2021, 57, 109 DOI: 10.1039/D0CC06169G
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