Issue 2, 2021

Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

Abstract

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.

Graphical abstract: Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

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Article information

Article type
Communication
Submitted
12 Nov 2020
Accepted
14 Dec 2020
First published
05 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 499-502

Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

K. Suzuki, Y. Takaoka and M. Ueda, RSC Chem. Biol., 2021, 2, 499 DOI: 10.1039/D0CB00204F

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