Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor†
We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.
- This article is part of the themed collections: The Chemical Biology of Peptides and RSC Chemical Biology Transparent Peer Review Collection