Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency

Robert Murphy; Shadi Kordbacheh; Dimitrios Skoulas; Simon Ng; Kasinan Suthiwanich; Andrea M. Kasko; Sally-Ann Cryan; Deirdre Fitzgerald-Hughes; Ali Khademhosseini; Amir Sheikhi; Andreas Heise

doi:10.1039/D1BM00275A

Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency†

Robert Murphy,^a Shadi Kordbacheh,^b Dimitrios Skoulas,

^a Simon Ng,

^bcd Kasinan Suthiwanich,

^bcde Andrea M. Kasko,

^b Sally-Ann Cryan,

^fgh Deirdre Fitzgerald-Hughes,

ⁱ Ali Khademhosseini,

^bcdjkl Amir Sheikhi

*^bcdm and Andreas Heise

*^agh

Author affiliations

* Corresponding authors

^a Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephens Green, Dublin 2, Ireland
E-mail: andreasheise@rcsi.ie

^b Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095-1600, USA

^c Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095-1600, USA

^d California NanoSystems Institute (CNSI), University of California, Los Angeles, Los Angeles, CA 90095-1600, USA

^e Department of Materials Science and Engineering, Tokyo Institute of Technology, Yokohama, Japan

^f Drug Delivery & Advanced Materials Team, School of Pharmacy, RCSI University of Medicine and Health Sciences, 123 St. Stephens Green, Dublin 2, Ireland

^g Centre for Research in Medical Devices (CURAM), RCSI University of Medicine and Health Sciences, and National University of Ireland, Dublin 2, Galway, Ireland

^h Advanced Materials and Bioengineering Research Centre (AMBER), RCSI University of Medicine and Health Sciences and Trinity College Dublin, Dublin 2, Ireland

ⁱ Department of Clinical Microbiology, RCSI University of Medicine and Health Sciences, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland

^j Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531 Boelter Hall, Los Angeles, CA 90095, USA

^k Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA

^l Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, USA

^m Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
E-mail: sheikhi@psu.edu

Abstract

Through rational design, block sequence controlled triblock copolypeptides comprising cysteine and tyrosine as well as a lysine or glutamic acid central block are devised. In these copolypeptides, each block contributes a specific property to the hydrogels to render them extrusion printable and antimicrobial. Three-dimensional (3D) printing of complex hydrogel structures with high shape retention is demonstrated. Moreover, composition dependent potent antimicrobial activity in contact-killing assays is elucidated.

Biomaterials Science

Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency

Social activity

Search articles by author

Spotlight

Advertisements