Issue 16, 2021

A novel fluorescence probe for the selective detection of cysteine in aqueous solutions and imaging in living cells and mice

Abstract

A novel fluorescent probe based on hydroxyquinoline conjugated with a charged trimethylindolenine unit Toc-Ac was developed, which exhibited long wavelength emission (560 nm) and a large Stokes shift (∼140 nm) due to the intrinsic mechanism of the intramolecular charge transfer process. The probe Toc-Ac showed a highly sensitive response to Cys (the detection limit was 3.86 × 10−8 M) in aqueous solution and was successfully applied for detecting endogenous Cys in living cells and mice.

Graphical abstract: A novel fluorescence probe for the selective detection of cysteine in aqueous solutions and imaging in living cells and mice

Supplementary files

Article information

Article type
Paper
Submitted
01 Feb 2021
Accepted
16 Mar 2021
First published
17 Mar 2021

Anal. Methods, 2021,13, 1965-1969

A novel fluorescence probe for the selective detection of cysteine in aqueous solutions and imaging in living cells and mice

H. Mei, D. Wang, M. Wang, X. Gu, X. Liu and L. Yang, Anal. Methods, 2021, 13, 1965 DOI: 10.1039/D1AY00178G

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