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Issue 14, 2021
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Advances in epitope molecularly imprinted polymers for protein detection: a review

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Abstract

Epitope molecularly imprinted polymers (EMIPs) are novel imprinted materials using short characteristic peptides as templates rather than entire proteins. To be specific, the amino acid sequence of the template peptide is the same as an exposed N- or C-terminus of a target protein, or its amino acid composition and sequence replicate a similar conformational arrangement as the same amino acid residues on the surface of the target protein. EMIPs have a good application prospect in protein research. Herein, we focus on classification of epitope imprinting techniques, methods of epitope immobilization on matrix materials including boronate affinity immobilization, covalent bonding immobilization, physical adsorption immobilization and metal ion chelation immobilization, and application of EMIPs in peptides, proteins, target imaging and target therapy fields. Finally, the main problems and future development are summarized.

Graphical abstract: Advances in epitope molecularly imprinted polymers for protein detection: a review

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Article information


Submitted
11 Jan 2021
Accepted
27 Mar 2021
First published
31 Mar 2021

Anal. Methods, 2021,13, 1660-1671
Article type
Critical Review

Advances in epitope molecularly imprinted polymers for protein detection: a review

X. Wang, G. Chen, P. Zhang and Q. Jia, Anal. Methods, 2021, 13, 1660
DOI: 10.1039/D1AY00067E

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