Issue 25, 2021

Development of a high-throughput device for liquid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of benzene derivatives in environmental water

Abstract

A device coupled with an automatic gas chromatography injection sampler for high-throughput liquid–liquid microextraction has been proposed in this study. This study's main objective was to devise a trap vial directly placed in an automatic liquid sampler (ALS) to collect and inject the extractant without a transfer step. Sixteen groups of microextraction procedures were performed simultaneously to increase the overall efficiency. The experimental parameters of the extraction method were optimized using a central composite design. Under the optimal conditions, the benzene derivatives' calibration curve was linear in the range of 0.1–200 μg L−1. The limit of detection (LOD) ranged from 0.016 to 0.16 μg L−1, and the limit of quantitation (LOQ) ranged from 0.046 to 0.50 μg L−1. The enrichment factors (EFs) ranged from 254 to 1094. Intraday and interday precision were found to be in the range of 2.2–6.2% (n = 3) and 4.0–6.3% (n = 9), respectively. The relative recovery of the four aqueous samples ranged from 69% to 121%. These experimental results indicated that the proposed device is reliable. Furthermore, it is simple, convenient and high-throughput.

Graphical abstract: Development of a high-throughput device for liquid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of benzene derivatives in environmental water

Supplementary files

Article information

Article type
Paper
Submitted
07 Jan 2021
Accepted
07 May 2021
First published
13 May 2021

Anal. Methods, 2021,13, 2865-2870

Development of a high-throughput device for liquid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of benzene derivatives in environmental water

Z. Li, Z. Guo, X. Chen, J. Liu, Y. Xu, Y. Wang and J. Zhao, Anal. Methods, 2021, 13, 2865 DOI: 10.1039/D1AY00038A

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