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Issue 5, 2021
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Multifunctional titanium phosphate carriers for enhancing drug delivery and evaluating real-time therapeutic efficacy of a hydrophobic drug component in Euphorbia kansui

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Abstract

Nanoparticles are often used to serve as drug delivery systems to improve the therapeutic efficacy of some hydrophobic drugs. In this work, PEG and peptide-modified titanium phosphate nanoparticles (TiP–PEG/peptide) were synthesized to enhance the drug delivery efficacy of tirucalla-8,24-diene-3β,11β-diol-7-one (KS-01), a major bioactive and hydrophobic component extracted from Euphorbia kansui. This drug delivery system with a loading efficiency of about 29.8 mg KS-01/1 g TiP–PEG/peptide exerted a significantly lower cell viability rate of MCF-7 than free KS-01, indicating that these carriers can effectively increase the therapeutic efficacy by improving its water solubility. Moreover, according to the fluorescence intensity of FAM which can be generated by caspase-3 cleaving DEVD-embedded peptide, the caspase-3 level could be determined and the therapeutic efficacy could be visualized in real time.

Graphical abstract: Multifunctional titanium phosphate carriers for enhancing drug delivery and evaluating real-time therapeutic efficacy of a hydrophobic drug component in Euphorbia kansui

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Article information


Submitted
26 Jan 2021
Accepted
05 Feb 2021
First published
05 Feb 2021

Analyst, 2021,146, 1620-1625
Article type
Paper

Multifunctional titanium phosphate carriers for enhancing drug delivery and evaluating real-time therapeutic efficacy of a hydrophobic drug component in Euphorbia kansui

D. Luo, Y. Zhang, M. Wang, C. Zhu, Y. Yao, W. Yao, L. Zhang and F. Cheng, Analyst, 2021, 146, 1620
DOI: 10.1039/D1AN00163A

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