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Issue 5, 2021
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Silver nanoparticle driven signal amplification for electrochemical chiral discrimination of amino acids

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Abstract

β-Cyclodextrin (β-CD) modified silver nanoparticles (AgNPs), denoted as β-CD/AgNPs, were prepared by a simple one-pot method. Due to the inherent chirality of β-CD, the developed β-CD/AgNPs exhibited higher affinity toward L-tyrosine (L-Tyr) than D-tyrosine (D-Tyr), leading to serious aggregation of AgNPs in the presence of L-Tyr. Consequently, the L-Tyr induced aggregation of AgNPs can result in signal amplification in the differential pulse voltammograms (DPVs) of L-Tyr, which can be applied for the electrochemical chiral discrimination of the Tyr enantiomers. Other chiral amino acids including tryptophan and phenylalanine can also be successfully discriminated with the β-CD/AgNPs, suggesting high universality of the developed chiral sensor.

Graphical abstract: Silver nanoparticle driven signal amplification for electrochemical chiral discrimination of amino acids

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Article information


Submitted
20 Jan 2021
Accepted
05 Feb 2021
First published
06 Feb 2021

Analyst, 2021,146, 1612-1619
Article type
Paper

Silver nanoparticle driven signal amplification for electrochemical chiral discrimination of amino acids

S. Wu, H. Wang, D. Wu, G. Fan, Y. Tao and Y. Kong, Analyst, 2021, 146, 1612
DOI: 10.1039/D1AN00119A

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