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Issue 37, 2020
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Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing

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Abstract

Injectable, drug-releasing hydrogel scaffolds with multifunctional properties including hemostasis and anti-bacterial activity are essential for successful wound healing; however, designing ideal materials is still challenging. Herein, we demonstrate the fabrication of a biodegradable, temperature-pH dual responsive supramolecular hydrogel (SHG) scaffold based on sodium alginate/poly(N-vinyl caprolactam) (AG/PVCL) through free radical polymerization and the subsequent chemical and ionic cross-linking. A natural therapeutic molecule, tannic acid (TA)-incorporated SHG (AG/PVCL-TA), was also fabricated and its hemostatic and wound healing efficiency were studied. In the AG/PVCL-TA system, TA acts as a therapeutic molecule and also substitutes as an effective gelation binder. Notably, the polyphenol-arm structure and diverse bonding abilities of TA can hold polymer chains through multiple bonding and co-ordinate cross-linking, which were vital in the formation of the mechanically robust AG/PVCL-TA. The SHG formation was successfully balanced by varying the composition of SA, VCL, TA and cross-linkers. The AG/PVCL-TA scaffold was capable of releasing a therapeutic dose of TA in a sustained manner under physiological temperature-pH conditions. AG/PVCL-TA displayed excellent free radical scavenging, anti-inflammatory, anti-bacterial, and cell proliferation activity towards the 3T3 fibroblast cell line. The wound healing performance of AG/PVCL-TA was further confirmed in skin excision wound models, which demonstrated the potential application of AG/PVCL-TA for skin regeneration and rapid wound healing.

Graphical abstract: Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing

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Supplementary files

Article information


Submitted
11 Jun 2020
Accepted
03 Aug 2020
First published
04 Aug 2020

J. Mater. Chem. B, 2020,8, 8585-8598
Article type
Paper

Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing

N. K. Preman, S. P. E. S., A. Prabhu, S. B. Shaikh, V. C., R. R. Barki, Y. P. Bhandary, P. D. Rekha and R. P. Johnson, J. Mater. Chem. B, 2020, 8, 8585
DOI: 10.1039/D0TB01468K

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