Janus dendritic silica/carbon@Pt nanomotors with multiengines for H2O2, near-infrared light and lipase powered propulsion

Abstract

Hybrid micro/nanomotors with multiple distinct propulsion modes are expected to improve their motion ability in complex body fluids. Herein, we report a multi-stimuli propelled Janus lipase-modified dendritic silica/carbon@Pt (DMS/C@Pt) nanomotor with built-in engines for hybrid propulsions of H₂O₂, light, and enzyme. The enhanced motion of the DMS/C@Pt nanomotor is achieved under the stimulus of H₂O₂ that produces an oxygen concentration gradient derived from the asymmetric catalysis of Pt nanoparticles. Irradiated with near-infrared (NIR) light, the uneven photothermal effect of the carbon part propels this nanomotor by self-thermophoresis. Besides, lipase is efficiently loaded into the dendritic pores, which decomposes triglyceride on the silica part and induces self-diffusiophoretic propulsion. These multiple propulsions shed light on the rational integration of various functional building blocks into one micro/nanomotor for complex tasks in biomedical applications.