Issue 40, 2020

Assessing the performance of rotational spectroscopy in chiral analysis

Abstract

The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.

Graphical abstract: Assessing the performance of rotational spectroscopy in chiral analysis

Article information

Article type
Minireview
Submitted
08 Jul 2020
Accepted
21 Sep 2020
First published
28 Sep 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 10863-10870

Assessing the performance of rotational spectroscopy in chiral analysis

S. R. Domingos, C. Pérez, M. D. Marshall, H. O. Leung and M. Schnell, Chem. Sci., 2020, 11, 10863 DOI: 10.1039/D0SC03752D

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