Issue 38, 2020

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

Abstract

Post translational modifications (PTM) such as phosphorylation are often correlated with tumorigenesis and malignancy in breast cancer. Herein, we report a PTM-assisted strategy as a simplified version of a personalized cancer vaccine for enhanced cancer immunotherapy. Titanium modified dendritic mesoporous silica nanoparticles (TiDMSN) are applied to assist the specific enrichment of phosphorylated tumor antigens released upon immunogenic cell death. This strategy significantly improved the tumor inhibition efficacy in a bilateral breast cancer model and the expansion of both CD8+ and CD4+ T cells in the distant tumor site. The nanotechnology based PTM-assisted strategy provides a simple and generalizable methodology for effective personalized cancer immunotherapy.

Graphical abstract: Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

Supplementary files

Article information

Article type
Edge Article
Submitted
17 May 2020
Accepted
09 Sep 2020
First published
10 Sep 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 10421-10430

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

S. Theivendran, J. Tang, C. Lei, Y. Yang, H. Song, Z. Gu, Y. Wang, Y. Yang, L. Jin and C. Yu, Chem. Sci., 2020, 11, 10421 DOI: 10.1039/D0SC02803G

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