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Issue 25, 2020
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pH-Responsive Au(i)-disulfide nanoparticles with tunable aggregation-induced emission for monitoring intragastric acidity

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Abstract

Aggregation-induced emission (AIE)-featuring Au(I) complexes are superior probes for physiological environment monitoring in living organisms owing to their excellent biocompatibility and efficient luminescent properties. However, the intrinsic obstacle of poor water stability and lack of response to biological stimuli greatly restrict their practical application in biological systems. Herein, water-stable and pH-responsive Au(I)-disulfide nanoparticles (NPs) with AIE characteristics were designed. The NPs were prepared by integrating a pH-responsive moiety, cysteine (Cys), into Au(I)-thiolate (SR) complexes, and the Au(I)-SR-Cys structure was formed through disulfide bonds. Hydrophilic Cys was located on the outer layer of the NPs, endowing the spherical NPs with high stability and remarkable monodispersity in water. In addition, Cys endowed the NPs with pH-responsive characteristics. These unique advantages enable them to hold great promise as luminescent probes to monitor intragastric acidity in an acid suppression therapy. To the best of our knowledge, this work is the first example of luminescent Au(I) materials to monitor physiological changes.

Graphical abstract: pH-Responsive Au(i)-disulfide nanoparticles with tunable aggregation-induced emission for monitoring intragastric acidity

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Supplementary files

Article information


Submitted
31 Mar 2020
Accepted
08 Apr 2020
First published
24 Apr 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 6472-6478
Article type
Edge Article

pH-Responsive Au(I)-disulfide nanoparticles with tunable aggregation-induced emission for monitoring intragastric acidity

J. Wang, J. Li, Y. Li, Z. Zhang, L. Wang, D. Wang, L. Su, X. Zhang and B. Z. Tang, Chem. Sci., 2020, 11, 6472
DOI: 10.1039/D0SC01843K

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