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Issue 25, 2020
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Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level

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Abstract

Infectious diseases caused by multidrug resistant (MDR) bacterial pathogens are impending threats to global health. Since delays in identifying drug resistance would significantly increase mortality, fast and accurate antibiotic susceptibility tests (ASTs) are critical for addressing the antibiotic resistance issue. However, the conventional methods for ASTs are always labor-intensive, imprecise, complex and slow (taking 2–3 days). To address these issues, some advanced microfluidic systems have been designed for rapid phenotypic and genotypic analysis of antibiotic resistance. This review highlights the recent development of microfluidics-based ASTs at the single-cell or single-molecule level for guiding antibiotic treatment decisions and predicting therapeutic outcomes.

Graphical abstract: Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level

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Article information


Submitted
06 Mar 2020
Accepted
01 Apr 2020
First published
01 Apr 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 6352-6361
Article type
Minireview

Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level

K. Zhang, S. Qin, S. Wu, Y. Liang and J. Li, Chem. Sci., 2020, 11, 6352
DOI: 10.1039/D0SC01353F

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