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Palladium-Catalyzed Asymmetric Hydrophosphorylation of Alkynes: Facile Access to P‑Stereogenic Phosphinates

Abstract

Despite the importance of P-chiral organophosphorus compounds in asymmetric catalysis, transition metal catalyzed methods to access P-chiral phosphine derivatives are still limited. Herein, a catalytic enantioselective method for the synthesis of P-stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation of alkynes. This process is demonstrated on a wide range of racemic phosphinates and leads to diverse P-stereogenic alkenylphosphinates directly.

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Article information


Submitted
21 Feb 2020
Accepted
20 Jun 2020
First published
29 Jun 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Accepted Manuscript
Article type
Edge Article

Palladium-Catalyzed Asymmetric Hydrophosphorylation of Alkynes: Facile Access to P‑Stereogenic Phosphinates

Z. Yang, X. Gu, L. Han and J. Wang, Chem. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0SC01049A

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