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Issue 14, 2020
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Dynamic pH responsivity of triazole-based self-immolative linkers

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Abstract

Gating the release of chemical payloads in response to transient signals is an important feature of ‘smart’ delivery systems. Herein, we report a triazole-based self-immolative linker that can be reversibly paused or slowed and restarted throughout its elimination cascade in response to pH changes in both organic and organic-aqueous solvents. The linker is conveniently prepared using the alkyne–azide cycloaddition reaction, which introduces a 1,4-triazole ring that expresses a pH-sensitive intermediate during its elimination sequence. Using a series of model compounds, we demonstrate that this intermediate can be switched between active and dormant states depending on the presence of acid or base, cleanly gating the release of payload in response to a fluctuating external stimulus.

Graphical abstract: Dynamic pH responsivity of triazole-based self-immolative linkers

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Supplementary files

Article information


Submitted
29 Jan 2020
Accepted
28 Feb 2020
First published
03 Mar 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 3713-3718
Article type
Edge Article

Dynamic pH responsivity of triazole-based self-immolative linkers

D. A. Roberts, B. S. Pilgrim, T. N. Dell and M. M. Stevens, Chem. Sci., 2020, 11, 3713
DOI: 10.1039/D0SC00532K

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