Issue 1, 2020

Single-cell identification by microfluidic-based in situ extracting and online mass spectrometric analysis of phospholipids expression

Abstract

This work describes a microfluidic system for in situ extraction of a single-cell and its phosphatidylcholine analysis through mass spectrometry. This approach uncovered cellular heterogeneity among seemingly identical cells and provided a new platform for identification and classification of cells.

Graphical abstract: Single-cell identification by microfluidic-based in situ extracting and online mass spectrometric analysis of phospholipids expression

Supplementary files

Article information

Article type
Edge Article
Submitted
11 Oct 2019
Accepted
11 Nov 2019
First published
11 Nov 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 253-256

Single-cell identification by microfluidic-based in situ extracting and online mass spectrometric analysis of phospholipids expression

Q. Huang, S. Mao, M. Khan, W. Li, Q. Zhang and J. Lin, Chem. Sci., 2020, 11, 253 DOI: 10.1039/C9SC05143K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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