Continuous one-flow multi-step synthesis of active pharmaceutical ingredients
Victor R. L. J.
Bloemendal, 
a
Mathilde A. C. H.
Janssen,
a
Jan C. M.
van Hest
*b
and
Floris P. J. T.
Rutjes
*a
a
Mathilde A. C. H.
Janssen,
a
Jan C. M.
van Hest
*b
and
Floris P. J. T.
Rutjes
*a
Abstract
During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.
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